Once an auto-campaign is live, you will need to pause it to make any changes to your enrollment rule or goals. 
Editing your Entry Rule
Editing, Adding, or Removing Goals
Editing your Entry Rule
If you edit your enrollment rule after a campaign has been started, this will not have any affect on the contacts currently in your auto-campaign. Once you restart your auto-campaign, only contacts who meet the new enrollment rule will be entered into the auto-campaign.
Editing, Adding, or Removing Goals
Editing a goal after an auto-campaign has started will have no effect on contacts who have already met that goal. Moving forward, it will only remove contacts who meet the updated goal.
Adding a new goal has no effect on the contacts who have already met other goals. Once you restart an auto-campaign with a new goal, the next time that auto-campaign processes all of the contacts who meet the new goal will be removed.
 
Removing a goal will have no effect on contacts who have already met that goal. It will simply stop removing contacts in the auto-campaign.